HCID 15077436, compound → 4-[2-(2-Methyl-1H-imidazol-1-yl)ethyl]piperidine

HRID 1650660Notes

Reaction equation

HRID 1650660 reaction equation
[CH3:1][C:2]1[N:3]([CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[CH:4]=[CH:5][N:6]=1.[H][H]>[Pt]=O.C(O)(=O)C>[CH3:1][C:2]1[N:3]([CH2:7][CH2:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:4]=[CH:5][N:6]=1

Participants

5

Reactant 2

HCID 15077436HCID 15077436, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 64846854-[2-(2-Methyl-1H-imidazol-1-yl)ethyl]piperidine

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

A suspension containing 41.8 g (0.22 mol) of the compound prepared in (a) above, 450 ml of glacial acetic acid and 5.4 g of platinum oxide in a pressure bottle was affixed to a Parr Hydrogenation apparatus under 50 psi. of hydrogen and maintained at room temperature until the hydrogen uptake was completed. The reaction mixture was filtered through Celite, and the filter bed was then washed with approximately 100 ml of acetic acid. The combined filtrates were then concentrated in vacuo and the resultant residue was distilled in a Kugelrohr apparatus to yield a low melting white solid.

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. washthe filter bed was then washed with approximately 100 ml of acetic acid
  3. concentrationThe combined filtrates were then concentrated in vacuo
  4. distillationthe resultant residue was distilled in a Kugelrohr apparatus
  5. customto yield

Sources & evidence

ORD record
ord-3567e1ed69f144d5be9826f9d092f2c9
Source dataset
uspto-grants-1990_05
Patent number
US04925851

Reaction notes

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