HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-(4-Chlorobenzyl)-4-hydroxy-7-methylbenzimidazole hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 2-(4-Chlorobenzyl)-4-methoxy-7-methylbenzimidazole | HCID 13971347 | — |
| Product | 2-(4-Chlorobenzyl)-4-hydroxy-7-methylbenzimidazole hydrobromide | HCID 23052386 | — |
Reaction Steps
A suspension of 2-(4-chlorobenzyl)-4-methoxy-7-methylbenzimidazole (4.0 g) in 48% aqueous hydrobromic acid (400 ml) under nitrogen was heated at 130° for 5 h, then evaporated to dryness in vacuo. The residue was recrystallized from ethanol-ether to afford the title compound (3.95 g), m.p. 275°-277° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04925853 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-5bb703b84ccb489d9ad50685be3b4537 |
| Source note | uspto-grants-1990_05 |