HCID 14751596, compound → HCID 14751597, compound

HRID 1650678Notes

Reaction equation

HRID 1650678 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[C:8]([CH2:15][N:16](C(OCC3C=CC=CC=3)=O)[CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[C:9]([O:13][CH3:14])=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[CH2:33][N:34](C(OCC1C=CC=CC=1)=O)[CH:35]1[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1>CO.[Pd]>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[C:8]([CH2:15][NH:16][CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[C:9]([O:13][CH3:14])=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[CH2:33][NH:34][CH:35]1[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1

Participants

4

Reactant 1

HCID 14751596HCID 14751596, compound

Product 1

HCID 14751597HCID 14751597, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1,6-dimethoxy-2,5-bis-[N-(cyclohexyl)benzyloxycarbonylaminomethyl)-naphthalene (250 mg) in methanol (10 ml) was hydrogenated at atmospheric pressure in the presence of 5% palladium-on-charcoal (50 mg) for 2 hours at room temperature. The catalyst was removed by filtration through Celite, and the filtrate was evaporated to afford the product as a yellow syrup; yield 60 mg (37%).

Workup

  1. customThe catalyst was removed by filtration through Celite
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-f12ad4716b9a4f139377d5e72fac7a91
Source dataset
uspto-grants-1990_05
Patent number
US04925831

Reaction notes

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