Fumarate → 5-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

HRID 1650706Notes

Reaction equation

HRID 1650706 reaction equation
[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][CH:3]=1.[C:13]([O-])(=O)/C=C/C([O-])=O>>[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH2:8][N:9]([CH3:13])[CH2:10][CH2:11][CH:12]=2)=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 5460307FumarateHCID 196125135-Methyl-2-(3-pyridyl)-thiazole

Product 1

HCID 196124795-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

Procedure

The title compound was prepared from 88 (2.2 g, 0.013 mol) by the procedure described in Example 49. The crude free base obtained, 89, was converted to the title fumarate, 90. Yield: 0.8 g (0.0032 mol, 25%). M.P. 159°-160° C. Anal. (C12H16N2O2S) C, H, N.

Workup

  1. customThe crude free base obtained

Sources & evidence

ORD record
ord-a0a7b3624597440d8520434a7d90b91e
Source dataset
uspto-grants-1990_05
Patent number
US04925858

Reaction notes

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