Dichloromethane → HCID 178458930, compound

Participants

Reaction Steps

A solution of 8.65 g of the product of Step F and 86 ml of methylene chloride was cooled to -70° C. to -60° C. and while maintaining this temperature, 116 ml of a solution of boron tribromide were added. After stirring for 24 hours, the temperature was allowed to return to ambient. The solution was poured into 180 ml of iced water and extracted with methylene chloride. The extracts were washed with water, dried and concentrated under reduced pressure. After chromatography under pressure (methylene-chloride - ethyl acetate 8-2), 4 g of the expected product were obtained which after crystallization from ethyl acetate melted at 232° to 234° C.

Provenance & Evidence