HCID 53893725, compound → HCID 14403425, compound

Participants

Reaction Conditions

Reaction Steps

460 mg (0.5 mmol) o& tris-triphenylphosphinyl rhodium chloride (=1 mol %, with respect to the reaction components) is added to a 100 ml autoclave. After purging with nitrogen, an air-free solution of 15.7 g (0.05 mol) of 4-chlorophenylethenyl 1-phenylmercapto-cyclopropyl ketone in 40 ml of toluene is added and heated at 50° C. under a hydrogen pressure of 30 bar. The hydrogen pressure is kept between 40 and 50 bar until the absorption of gas is complete. The mixture is subsequently reacted for 1 hour. For working up, the solvent is removed under reduced pressure and the residue which remains is purified on silica gel using dichloromethane as the eluant. 14.2 g (90% of theory) of 4-chlorophenylethyl 1-phenylmercaptocyclopropyl ketone are obtained in the form of an oily product.

Provenance & Evidence