Benzyl Bromide → HCID 53945212, compound

Participants

Reaction Steps

5 g of ethyl (2,3-dihydro-2-oxo-4-trifluoromethyl-thiazol-5-yl)-carboxylate (CA Vol. 92 110 998P), 80 ml of toluene, 1.16 g of potassium hydroxide, 3.7 ml of benzyl bromide and 1.61 g of tetrabutyl-ammonium bromide were heated at 70° C. for 7 hours and the mixture was allowed to return to ambient temperature, and was decanted, washed and dried to obtain 7.2 g of product which was chromatographed on silica. Elution with a hexane-isopropyl ether mixture (8-2) yielded 5.46 g of the expected product with a Rf=0.17.

Provenance & Evidence