Boron trifluoride etherate → HCID 20061642, compound

Participants

Reaction Steps

3.13 g of the product of Step A, 30 ml of toluene and 1.3 ml of boron trifluoride etherate were stirred for 30 minutes at -65° to -70° C. and 48 ml of 1.2M solution of diisobutyl aluminium hydride in toluene were added over 2 hours. The mixture was poured into an iced molar solution of sodium and potassium tartrate and after stirring for one hour and decanting, extraction was carried out with ethyl acetate. The extracts were washed, dried and brought to dryness and the residue was chromatographed on silica. Elution with a hexaneisopropyl ether mixture (1-1) yielded 2.16 g of the expected product with a Rf=0.1.

Provenance & Evidence