反应详情

6.7 g (0.02 mol) of 3-(tert-butyl)-5-(N-methylamino)-1-(2,4,6-trichlorophenyl)-1H-1,2,4-triazole was added to 51 g (0.5 mol) of acetic anhydride, and the mixture was stirred under reflux for 1 hour. Then, excess acetic anhydride was distilled off under reduced pressure. The residue was purified by silica gel column chromatography to obtain 5.5 g (yield: 73.3 g) of the desired compound as white powder. Melting point: 93°-94° C.

1. temperatureunder reflux for 1 hour
2. distillationThen, excess acetic anhydride was distilled off under reduced pressure
3. customThe residue was purified by silica gel column chromatography