Cetyl Alcohol → Propylparaben

HRID 1650784Notes

Reaction equation

HRID 1650784 reaction equation
C(OCCCC)(=O)CC[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH2:14][CH2:15]C)=[O:11].C([OH:39])CCCCCCCCCCCCCCC>O>[CH2:13]([O:12][C:10]([C:9]1[CH:4]=[CH:5][C:6]([OH:39])=[CH:7][CH:8]=1)=[O:11])[CH2:14][CH3:15]

Participants

4

Reactant 2

HCID 2682Cetyl AlcoholHCID 7986Dibutyl decanedioate

Product 1

HCID 7175Propylparaben

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

The SQ 30,741 and parabens are mixed with dibutyl sebacate with gentle heat, not over 50° C., and melted together and Polysorbate 60 and cetyl alcohol added. Water is heated to 80° C. to dissolve the sodium carboxymethyl cellulose forming an aqueous phase which is added with vigorous agitation to the oil phase to emulsify. Agitation is continued until the temperature drops down to 48° C. Sufficient 50° C. water is added to make 100 gm. Mixing is continued at a slow rate to congeal the mixture, until the lotion drops down to room temperature.

Workup

  1. additionis added with vigorous agitation to the oil phase
  2. customdrops down to 48° C
  3. additionMixing
  4. customdrops down to room temperature

Sources & evidence

ORD record
ord-4d3e95c3f5404e17981b9ba9adc1cb02
Source dataset
uspto-grants-1990_05
Patent number
US04925873

Reaction notes

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