2,6-Difluorobenzoyl isocyanate → HCID 23052547, compound

HRID 1650806Notes

Reaction equation

HRID 1650806 reaction equation
[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[Cl:14][C:15]1[CH:21]=[C:20]([O:22][C:23]([F:29])([F:28])[C:24]([F:27])([F:26])[F:25])[C:19]([Cl:30])=[CH:18][C:16]=1[NH2:17]>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[C:3]=1[C:4]([NH:6][C:7]([NH:17][C:16]1[CH:18]=[C:19]([Cl:30])[C:20]([O:22][C:23]([F:29])([F:28])[C:24]([F:25])([F:26])[F:27])=[CH:21][C:15]=1[Cl:14])=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 27333692,6-Difluorobenzoyl isocyanateHCID 23052545HCID 23052545, compound

Product 1

HCID 23052547HCID 23052547, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

3.4 g of 2,6-difluorobenzoyl isocyanate, dissolved in 10 ml of dry toluene, are added at room temperature and with the exclusion of moisture to 5.6 g of 2,5-dichloro-4-pentafluoroethoxyaniline dissolved in 40 ml of dry toluene, and the batch is stirred for 10 hours. Approximately 60% of the solvent is then removed. The precipitate formed is filtered off with suction, washed with hexane and dried in vacuo. The title compound of formula ##STR15## is obtained in the form of colourless crystals; m.p. 178°-179° C.

Workup

  1. customApproximately 60% of the solvent is then removed
  2. customThe precipitate formed
  3. filtrationis filtered off with suction
  4. washwashed with hexane
  5. customdried in vacuo

Sources & evidence

ORD record
ord-579433010616476ca99e56ebaf2b6fe9
Source dataset
uspto-grants-1990_05
Patent number
US04925875

Reaction notes

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