Potassium Hydroxide → HCID 18358260, compound

HRID 1650807Notes

Reaction equation

HRID 1650807 reaction equation
[C:1]1([C:7]([N:10]([CH:12]=[C:13](Br)[CH3:14])[CH3:11])([CH3:9])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>>[C:1]1([C:7]([N:10]([C:12]#[C:13][CH3:14])[CH3:11])([CH3:8])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 86743933HCID 86743933, compound

Product 1

HCID 18358260HCID 18358260, compoundYield 98%

Procedure

21.92 g of N-1-phenylisopropyl-N-methyl-2-bromo-propenyl amine are dissolved in 320 ml of alcohol and 40 ml of a 50% aqueous potassium hydroxide solution are added. The mixture is refluxed for 216 hours. The alcohol is distilled off and to the residue water is added and the mixture is extracted with benzene. The benzene solution is dried over potassium carbonate and evaporated. The residue is distilled off in vacuo. At 104°-110° C., 5 Hgmm 15 g of N-1-phenylisopropyl-N-methyl-propynylamine are obtained as a main fraction. nD20.4 =1.5229.

Workup

  1. temperatureThe mixture is refluxed for 216 hours
  2. distillationThe alcohol is distilled off and to the residue water
  3. additionis added
  4. extractionthe mixture is extracted with benzene
  5. dry with materialThe benzene solution is dried over potassium carbonate
  6. customevaporated
  7. distillationThe residue is distilled off in vacuo

Sources & evidence

ORD record
ord-7ffba0afdb8b40ff94ec6c80742413e7
Source dataset
uspto-grants-1990_05
Patent number
US04925878

Reaction notes

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