p-Toluenesulfonic acid → HCID 15032037, compound

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Reaction Conditions

Reaction Steps

To a 100 ml 3-neck round bottom flask is charged 8.9 g product of Example 4 in 30 ml toluene. To this is added 0.8 g p-toluenesulfonic acid. Isobutylene is passed through the solution while warming to 90° C. When TLC shows the reaction to be complete, the contents are diluted with an equal volume to ethyl acetate and washed 2 times with 50 ml of 5% sodium bicarbonate. The organic layer is dried, and stirpped under vacuu. The residue is purified by dry column chromatography to give 3.3 g white solids. Further purification by precipitation from a water/methanol solution gives 2.4 g of product. Calc. for C57H87N3O6 : C, 75.19; H, 9.65; N, 4.62;

Provenance & Evidence