HCID 14267830, compound → HCID 70360267, compound

Participants

Reaction Steps

6-Acetoxymethyl-5-(2,5-dimethoxyanilino)methylpyrido[2,3-d]-pyrimidine-2,4(1H,3H)-dione (400 mg, 1 mmol) in diphenyl ether is heated at 210° C. for 2 hours under nitrogen. The resulting clear solution is cooled and then is diluted with a 1:1 mixture of ethanol and diethyl ether (100 mL). The yellow precipitate is collected by filtration and is washed with boiling mixture of chloroform and ethanol (1:1 v/v) to give 6-(2,5-dimethoxyphenyl)-6,7-dihydropyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione (311 mg, 91%), mp 308°-310° C. 1H NMR (Me2SO-d6) d 3.70 (3H, s, OMe), 3.74 (3H, s, OMe), 4.67 (2H, brs, CH2), 4.98 (2H, brs, CH2), 6.28 (1H, s, H-6'), 6.31 and 6.87 (each 1H, d, H-3' and H-4' ), 8.53 (1H, s, H-2), 11.43 and 11.61 (each 1H, brs, NH, exchangeable).

Provenance & Evidence