Pyridine → HCID 23050855, compound

HRID 1650990Notes

Reaction equation

HRID 1650990 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9](CNC(=O)[O-])(=[O:11])=[O:10].[CH3:17][C:18]1[CH2:22][CH2:21][NH:20][N:19]=1.[N:23]1[CH:28]=CC=CC=1.[O:29]1CCOCC1>>[F:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[S:9]([NH:23][C:28]([N:20]1[CH2:21][CH2:22][C:18]([CH3:17])=[N:19]1)=[O:29])(=[O:10])=[O:11]

Participants

5

Reactant 4

HCID 1049PyridineHCID 312751,4-DioxaneHCID 5580923-Methyl-4,5-dihydro-1H-pyrazoleHCID 86743940HCID 86743940, compound

Product 1

HCID 23050855HCID 23050855, compound

Procedure

A mixture of 2.51 g of N-(2,6-difluorophenylsulphonyl)methylcarbamate, 1.68 g of 3-methyl-2-pyrazoline and 3 ml of pyridine in 20 ml of dioxane is heated on a steambath for 2 hours. After cooling the solvent is evaporated under reduced pressure and the residue is dissolved in 20 ml of water. This solution is filtrated and then acidified with conc. hydrochloric acid. The title compound, viz. 1-(2,6-difluorophenylsulphonylcarbamoyl)-3-methyl-2-pyrazoline, is obtained in a yield of 2.50 g; melting point 196° C.

Workup

  1. temperatureis heated on a steambath for 2 hours
  2. temperatureAfter cooling the solvent
  3. customis evaporated under reduced pressure
  4. dissolutionthe residue is dissolved in 20 ml of water
  5. filtrationThis solution is filtrated

Sources & evidence

ORD record
ord-d006e923622e4ffb9037d1255c6feaa5
Source dataset
uspto-grants-1990_05
Patent number
US04927452

Reaction notes

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