Thiophene → HCID 70360094, compound

Participants

Reaction Steps

A mixture of 46.4 parts of 2,3,4,4a,10,10a-hexahydro-9(1H)phenanthrenone, 58 parts of methyl glycine monohydrochloride, 2 parts of a solution of thiophene in methanol 4%, 480 parts of methanol and 26.1 parts of potassium fluoride was hydrogenated at normal pressure and at 50° C. with 3.0 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was taken up in water and 1,1'-oxybisethane. The whole was treated with a sodium hydroxide solution. The separated organic layer was dried, filtered and evaporated, yielding 59.5 parts (93.8%) of methyl N-(1,2,3,4,4a,9,10,10a-octahydro-9-phenanthrenyl)glycine as a residue (int. 6).

Provenance & Evidence