Hexane → HCID 14458736, compound

Participants

Reaction Steps

To a mixture of 6-o-tolyloxy-2-picoline amidine hydrochloride (3 g) and methanol (100 ml) were added 28% sodium methoxide solution in methanol (3.3 g) and 1,1-dimethoxybutanone (1.9 g). The mixture was heated under refluxing for an hour, and was left to stand at room temperature. The reaction solution was concentrated under reduced pressure, and the residue obtained was subjected to silica gel column chromatography (eluent; n-hexane: ethyl acetate=2:1 in volume) to obtain 4-methyl-2-(6-o-tolyloxy-2-pyridinyl)pyrimidine (2.4 g, yield 76%).

Provenance & Evidence