関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | HCID 178508854 | HCID 178508854 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 生成物 | HCID 178474468 | HCID 178474468 | 84% |
反応手順
A suspension of 0.88 g of 2-amino-4-hydroxy-6-[2-(4-carboxyphenyl)ethenyl]pyrido[2,3-d]-pyrimidine in 20 mL of acetic anhydride containing 0.05 g of 4-dimethylaminopyridine was heated under nitrogen at 120° C. for 3 hours. The reaction mixture was cooled to room temperature. Fifty milliliters of ether were added and the resulting yellow solid was collected by filtration to yield 0.95 g (84%) of 2-acetamido-4-hydroxy-6-[2-(4-acetoxycarbonylphenyl)ethenyl]-pyrido[2,3-d]pyrimidine; mp>300° C.; IR (Nujol) 3350, 3150, 1800, 1670, 1600 cm-1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04927828 |
|---|
| 出典データセット | uspto-grants-1990_05 |
|---|
| ORD ID | ord-b4c8d5bb01f14225bf8fa1b450ded371 |
|---|
| 出典メモ | uspto-grants-1990_05 |
|---|
