Acetic Acid → HCID 178487029, compound

HRID 1651073Notes

Reaction equation

HRID 1651073 reaction equation
CO[C:3]1[CH:29]=[CH:28][C:6]2[CH:7](COS(C3C=CC(C)=CC=3)(=O)=O)[C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2C=1.[C:30]([O-:33])(=O)[CH3:31].[Na+].[OH-:35].[K+].[C:37](O)(=O)C>CO>[CH3:37][O:35][C:5]1[CH:6]=[CH:28][C:29]2[CH:3]=[C:30]([OH:33])[CH:31]=[CH:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=3[C:10]=2[CH:11]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 14797Potassium HydroxideHCID 517045Sodium AcetateHCID 86743950HCID 86743950, compound

Product 1

HCID 178487029HCID 178487029, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methoxy-5-p-toluenesulphonyloxymethyldibenzo[a,d]cycloheptene (13.5 g) in glacial acetic acid (100 ml) was added anhydrous sodium acetate (5.6 g). The reaction mixture was heated under reflux for 15h then the solvent was removed under vacuum to leave a residue which was partitioned between dichloromethane (3×120 ml) and water (120 ml). The combined organic layers were dried (Na2SO4), filtered and concentrated in vacuo to leave a residue which was dissolved in 75% aqueous methanol (100 ml) and treated with potassium hydroxide at 0° C. until the pH was approximately 12. After 3h the reaction mixture was concentrated in vacuo and the presidue partitioned between water (100 ml) and diethyl ether (3100 ml). The combined organic layers were dried (Na2SO4). filtered and concentrated in vacuo. Chromatography of the residue on flash silica with 10% ethyl acetate in hexane as eluent initially gave the less polar isomer, 2-methoxy-6-hydroxy-dibenzo [c,e]cyclooctene (1.6 g), m.p. 97°-99° C. δ (360 MHz, CDCl3) 3.25 (1H. dd, J=13.8 and 10.0 Hz, CHAHB --CHCOH), 3.39 (1H, dd, J=13.8 and 6.2 Hz, CHAHBCHCOH), 3.72 (3H, s, OCH3), 5.23 (1H, dd, J=10.0 and 6.2 Hz, CHAHB --CHC --OH), 6.61 (1H, d, J=2.7 Hz, CH=C(OCH3)--CH=CH), 6.70 (1H, dd, J=8.4 and 2.7 Hz, CH=C(OCH3)--CH=CH), 6.77 (1H, d, J=11.9, ArCH=CH--Ar), 6.87 (1 H, d, J=11.9 Hz, Ar--CH=CH--Ar), 7.09-7.21 (3H, m aromatics), 7.16 (1H, dd, J=8.5 and 2.7 Hz, CH=C(OCH3)--CH=CH) and 7.44 (1H, dd, J=8.6 and 2.7 Hz, CH=C--CH2OH). Irradiation of HB (δ3.39) gave a n.o.e to the proton at δ7.16 which is on the same ring as the methoxy group and irradiation of HC (δ5.23) gave a n.o.e to the proton at δ7.45 which is on the other aromatic ring. m/e 252 (M+). i.r. (νmax nujol mull) 3400-3100 cm-1 (br, OH). Found: C, 78.8; H, 6.5. C17H16O2.0.35 H2O requires: C, 78.9; H, 6.5%. The more polar product next obtained, as an oil, was 2-methoxy-5-hydroxymethyldibenzo[a,d]cycloheptene (5.2 g, 62%). 2-Methoxy-5-hydroxydibenzo[a,e]cyclooctene was not isolated.

Workup

  1. temperatureThe reaction mixture was heated
  2. customthe solvent was removed under vacuum
  3. customto leave a residue which
  4. customwas partitioned between dichloromethane (3×120 ml) and water (120 ml)
  5. dry with materialThe combined organic layers were dried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo
  8. customto leave a residue which
  9. concentrationAfter 3h the reaction mixture was concentrated in vacuo
  10. customthe presidue partitioned between water (100 ml) and diethyl ether (3100 ml)
  11. dry with materialThe combined organic layers were dried (Na2SO4)
  12. filtrationfiltered
  13. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6135fca31fc84f068c48d77993f35cc6
Source dataset
uspto-grants-1990_05
Patent number
US04927819

Reaction notes

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