Dimethylamine → HCID 14751337, compound

HRID 1651130Notes

Reaction equation

HRID 1651130 reaction equation
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([CH:17]=[CH:18][C:19]=1[OH:20])[C:8]([C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=1)=[O:9])([CH3:4])[CH3:3].[CH3:21][NH:22][CH3:23].C=O.[CH2:26](O)[CH3:27]>>[CH3:21][N:22]([CH2:26][CH2:27][C:18]1[CH:17]=[C:7]([CH:6]=[C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])[C:19]=1[OH:20])[C:8]([C:10]1[CH:11]=[CH:12][C:13]([CH3:16])=[CH:14][CH:15]=1)=[O:9])[CH3:23]

Participants

5

Reactant 4

HCID 674DimethylamineHCID 702EthanolHCID 712FormaldehydeHCID 23051460HCID 23051460, compound

Product 1

HCID 14751337HCID 14751337, compound

Procedure

3-(1,1-Dimethylethyl)-4-hydroxy-4'-methylbenzophenone (2.68 g) was suspended in 45 ml of ethanol and heated with stirring to reflux for 8 hours with 1.80 g of a 50% aqueous solution of dimethylamine and 1.7 g of a 35% aqueous solution of formaldehyde. Insoluble material was filtered off, the filtrate evaporated to dryness in vacuo, and the residue crystallized from ethanol to give 2.36 g of white crystals, m.p. 123°-124.5° C.

Workup

  1. temperatureheated
  2. filtrationInsoluble material was filtered off
  3. customthe filtrate evaporated to dryness in vacuo
  4. customthe residue crystallized from ethanol

Sources & evidence

ORD record
ord-751b39cb002b409cb8f87db364c79b70
Source dataset
uspto-grants-1990_05
Patent number
US04927835

Reaction notes

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