Sodium Hydroxide → HCID 14742800, compound

Participants

Reaction Steps

As in Example 112, (E)-3-[3,4-dihydro-6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid methyl ester (2.5 g) in methanol (15 mL) was heated at reflux with 1N sodium hydroxide solution (11 mL) at reflux for 1 hour. The usual work up furnished 2 g of (E)-3-[3,4-dihydro-6-methoxy-1-(4-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid. Crystallization of a small sample from dichloromethane-ethyl acetate gave the analytical specimen, mp 222°-224° C. Anal. Calcd for C21H20O4 : C, 74.98; H, 5.99 Found: C, 74.89; H, 6.00

Provenance & Evidence