Sodium Hydroxide → (E)-3-(1-butyl-4-methoxy-2-naphthalenyl)-2-propenoic acid

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Reaction Steps

As in Example 112, (E)-3-(1-butyl-4-methoxy-2-naphthalenyl)-2-propenoic acid methyl ester (4 g) in methanol (20 mL) was treated with 2N sodium hydroxide solution (5 mL) at reflux for 1 hour and the normal isolation procedure afforded 3.8 g of (E)-3-(1-butyl-4-methoxy-2-naphthalenyl)-2-propenoic acid. Crystallization of a sample from diethyl ether gave the analytical specimen, mp 166°-167° C. Anal. Calcd for C18H20O3 : C, 76.03; H, 7.09 Found: C, 75.89; H, 7.13

Provenance & Evidence