反应详情

A solution of crude 7-methoxy-1-(3-methoxyphenyl)-2-naphthalenecarboxylic acid ethyl ester (4.1 g) in a mixture of methanol (20 mL) and 4N potassium hydroxide (5 mL) was heated at reflux for 3 hours. After the methanol was evaporated off, the reaction was diluted with water and extracted with ether (2×25 mL). The aqueous layer was acidified, extracted with dichloromethane (3×25 mL) and the dried (MgSO4) extracts evaporated to give 3.9 g of crude 7-methoxy-1-(3-methoxyphenyl)-2-naphthalenecarboxylic acid. Crystallization from toluene-hexane provided 3.05 g of acid, mp 164°-168° C. Anal. Calcd for C19H16O4 : C, 74.01; H, 5.23 Found: C, 73.58; H, 5.49

1. temperaturewas heated
2. temperatureat reflux for 3 hours
3. customAfter the methanol was evaporated off
4. additionthe reaction was diluted with water
5. extractionextracted with ether (2×25 mL)
6. extractionextracted with dichloromethane (3×25 mL)
7. dry with materialthe dried (MgSO4)
8. customextracts evaporated