Pyridine, 3-(4-aminobutyl)- → HCID 23051615, compound

Participants

Reaction Steps

As in Example 114, (E)-3-[7-methoxy-1-(3-methoxyphenyl)-2-naphthalenyl]-2-propenoic acid 4-nitrophenyl ester (1.2 g) was reacted with 3-pyridinebutanamine (0.46 g) in tetrahydrofuran (12 mL) for 2 hours at room temperature. The crude product, isolated in the usual manner was purified by using HPLC (ethyl acetate) and then was crystallized from diethyl ether to yield 0.83 g of (E)-3-[7-methoxy-1-(3-methoxyphenyl)-2-naphthalenyl]-N-[4-(3-pyridinyl)butyl]-2-propenamide, mp 108.5°-110° C. Anal. Calcd for C30H30N2O3O.15 H2O: C, 76.78; H, 6.51; N, 5.97; H2O, 0.57 Found: C, 76.68; H, 6.51; N, 6.04; H2O, 0.57

Provenance & Evidence