1-Methylpiperazine → 6-Methoxy-3-pentyl-2-benzofurancarboxaldehyde

Participants

Reaction Steps

As in Example 152, sodium bis(2-methoxyethoxy)aluminum hydride in toluene (3.4M; 33.6 mL) and toluene (30 mL) pretreated with N-methypiperazine (13.5 mL) in toluene (20 mL) was reacted with 6-methoxy-3-pentyl-2-benzofurancarboxylic acid ethyl ester (6 g) in toluene (90 mL) for 30 minutes at -45° C. The previously described work up yielded 4.82 g of 6-methoxy-3-pentyl-2-benzofurancarboxaldehyde as an oil.

Provenance & Evidence