HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → (E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester | HCID 17453 | — |
| Reactant | 6-Methoxy-3-pentyl-2-benzofurancarboxaldehyde | HCID 14742773 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid methyl ester | HCID 14742791 | 76.9% |
Reaction Steps
As in Example 111, 6-methoxy-3-pentyl-2-benzofurancarboxaldehyde (4.82 g) and (carbomethoxymethylene)triphenylphosphorane (6.7 g) in dichloromethane (75 mL) was stirred at room temperature for 42 hours. Purification of the crude reaction product by HPLC (diethyl ether-hexane; 1:12) gave 4.55 g of (E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid methyl ester as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04927838 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-57fb68fcd4054cc9baebdb4ddad14b9f |
| Source note | uspto-grants-1990_05 |