Sodium Sulfate → HCID 14028992, compound

Participants

Reaction Steps

130 parts of anhydrous sodium sulfate were suspended in a solution of 305 parts of 3-cyano-2,4-difluoro-6-nitro-quinoline in 3,400 parts of tetrahydrofuran. 30 parts of a hydrogenation catalyst (10% palladium on carbon) were added, which was followed by hydrogenation at 40° C. and 3 bar. After the uptake of hydrogen had ended, the suspension was filtered, and the clear solution was added to 6,000 parts of ice-water. The resulting precipitate was filtered off with suction, washed and dried. This gave 198 parts of 6-amino-3-cyano-2,4-difluoroquinoline, corresponding to a yield of 74%.

Provenance & Evidence