Sulfuric Acid → HCID 4581090, compound

Participants

Reaction Steps

To 25 g (0.27 mmol) of epichlorohydrin, 20.8 g (0.27 mmol) of methylcellosolve and 0.1 ml of conc. sulfuric acid were added and reacted for 10 hours at 100° C. After the reaction, 500 ml of ether was added and washed with saturated sodium hydrogen carbonate solution and with saturated sodium chloride solution. The ether phase was dried on magnesium sulfate, filtered and concentrated to give 20 g of 1-chloro-2-hydroxy-3-(2'-methoxyethoxy)propane. 1H-NMR (CDCl3): δ=3.40 (3H, s, --OCH3), 3.45-3.82 (9H, m, H1, H3, H1', H2', --OH), 3.84-4.18 (1H, m, H2).

Provenance & Evidence