HCID 86743958, compound → HCID 86743959, compound

Participants

Reaction Steps

A solution of 10.7 g (43.4 mmol) of methyl (E)-4-hydroxy-6-(4-methoxyphenyl)-5-hexen-2-ynoate in 150 ml of methylene chloride was added dropwise at 0° to a suspension of 56.7 g (652 mmol) of manganese dioxide in 200 ml of methylene chloride. The reaction mixture was stirred at 0° for 2 hours, filtered over magnesium sulphate and concentrated. Crystallization of the residue from ether yielded methyl (E)-6-(4-methoxyphenyl)-4-oxo-5-hexen-2-ynoate of melting point 70°.

Provenance & Evidence