HCID 86743960, compound → HCID 86743961, compound

Participants

Reaction Steps

A solution of 2.4 g (7.2 mmol) of 2-(2-methoxyethoxy)-ethyl (E)-4-hydroxy-6-(4-methoxyphenyl)-5-hexen-2-ynoate in 40 ml of methylene chloride was added dropwise at 0° to a suspension of 9.4 g (108 mmol) of manganese dioxide in 30 ml of methylene chloride. The reaction mixture was stirred at 0° for 2 hours, filtered over magnesium sulphate and concentrated. Crystallization of the residue from ether/hexane yielded 2-(2-methoxyethoxy)ethyl (E)-6-(4-methoxyphenyl)-4-oxo-5-hexen-2-ynoate of melting point 41°-42°.

Provenance & Evidence