HCID 10044233, compound → HCID 10360184, compound

Participants

Reaction Steps

A solution of 0.57 g (1.5 mmoles) of 1-cyclopropyl-6,8-difluoro-7-(3-carbamoyl-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (example 6) in 12 ml of acetic anhydride is heated under reflux for 24 hours. Cooling, filtering and washing with water and ethanol yield 0.15 g (27%) of 1-cyclopropyl-6,8-difluoro-7-(3-cyano-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid melting at >325° C.

Provenance & Evidence