Acetic Acid → HCID 10043398, compound

Participants

Reaction Steps

A solution of 0.8 g (1.6 mmoles) of 7-(3-trifluoroacetamidomethyl-1-azetidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (example 9) in 30 ml of 1N sodium hydroxide is maintained at 80° C. for 3 hours, cooled and acidified with acetic acid. Filtering and washing yield 0.41 g (65%) of 7-(3-aminomethyl-1-azetidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid melting at 190°-195° C.

Provenance & Evidence