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HRID1651391

反应详情

EQUATION

反应方程式

HRID 1651391 的结构方程式

REACTANTS

反应物

1
结构：CCOC(=O)c1cn(C2CC2)c2c(F)c(N3CC(OS(C)(=O)=O)C3)c(F)cc2c1=O
HCID15615454

未命名化合物

PRODUCTS

生成物

1
结构：CS(=O)(=O)OC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C1
HCID10093202

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCO
溶剂HCID702

Ethanol

C2H6O

结构：[Na+].[OH-]
溶剂HCID14798

Sodium Hydroxide

HNaO

PROCEDURE

实验过程

A solution of 0.2 g (0.4 mmole) of ethyl 1-cyclopropyl-6,8-difluoro-7-(3-mesyloxy-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate (example 3) in 6 ml of 0.5N sodium hydroxide and 1 ml of ethanol is refluxed for 1 hour. It is evaporated under vacuum, and acetic acid is added. Filtering and washing yield 0.18 g (96%) of 1-cyclopropyl-6,8-difluoro-7-(3-mesyloxy-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid melting at 240°-4° C.

WORKUP

后处理

  1. customIt is evaporated under vacuum, and acetic acid
  2. additionis added
  3. filtrationFiltering
  4. washwashing yield 0.18 g (96%) of 1-cyclopropyl-6,8-difluoro-7-(3-mesyloxy-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid melting at 240°-4° C.