HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → E 4441
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 535414 | — |
| Reactant | 3-Methylazetidin-3-amine dihydrochloride | HCID 14852453 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | E 4441 | HCID 130229 | — |
Reaction Steps
A mixture of 0.23 g (0.82 mmoles) of 1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, 0.26 g (1.64 mmoles) of 3-methyl-3-aminoazetidine dihydrochloride and 0.5 ml of triethylamine is refluxed in 10 ml of pyridine for 2 hours. Filtering and washing with water and ethanol yield 0.250 g (87%) of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-3-amino-1-azetidinyl)-4-oxo-3-quinolinecarboxylic acid having a melting point and spectroscopic data identical to those of the derivative obtained by Method E.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04927926 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-119b2f06835f4fe4af10f127b55306f6 |
| Source note | uspto-grants-1990_05 |