反应详情

A solution of 1.25 g (2.5 mmoles) of 1-(4-fluorophenyl)-6,8-difluoro-7-(3-amino-3-trifluoroacetamido-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (example 19), in 8 ml of 1N sodium hydroxide and 10 ml of water is heated under reflux for 3 hours. It is cooled, filtered, and acetic acid is added. After filtering and washing with water and cold ethanol, 0.8 g (72%) of 1-(4-fluorophenyl)-6,8-difluoro-7-(3-amino-3-methyl-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid are obtained, melting at 272°-7° C.

1. temperatureunder reflux for 3 hours
2. temperatureIt is cooled
3. filtrationfiltered
4. additionacetic acid is added
5. filtrationAfter filtering
6. washwashing with water and cold ethanol, 0.8 g (72%) of 1-(4-fluorophenyl)-6,8-difluoro-7-(3-amino-3-methyl-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
7. customare obtained