HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 9980729, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | — |
| Reactant | 133891-75-5 | HCID 14852458 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 9980729 | HCID 9980729 | 91.5% |
Reaction Steps
A mixture of 0.7 g (2.6 mmoles) of 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, 0.92 g (3.96 mmoles) of 3-methyl-3-trifluoroacetamidomethylazetidine hydrochloride and 1.6 g of triethylamine are heated under reflux for 2 hours in 12 ml of pyridine. The mixture is evaporated, water is added, the product is filtered, and 1.05 g (90%) of 1-cyclopropyl-6-fluoro-7-(3-trifluoroacetamidomethyl-3-methyl-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid are obtained, melting at 265°-72° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04927926 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-2265ce8f80464777bc725ac2f537e602 |
| Source note | uspto-grants-1990_05 |