HCID 56999329, compound → HCID 10090730, compound

Participants

Reaction Steps

A solution of 0.78 g (3.5 mmoles) of 1-cyclopropyl-6-fluoro-7-(3-trifluoroacetamidoethylaminomethyl-3-methyl-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (example 31) is heated under reflux for 3 hours in 15 ml of sodium hydroxyde 1N and 6 ml of ethanol then evaporated under vacuum. The mixture is cooled, acetic acid is added, filtrated and washed with water to obtain 0.4 g (65%) of 1-cyclopropyl-6-fluoro-7-(-3-ethylaminomethyl-3-methyl-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid melting at 221°-6° C.

Provenance & Evidence