HRID1651439

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)O

HCID5702571

N-[1(S)-Ethoxycarbonyl-3-phenylpropyl]-L-alanine

C15H21NO4

HCID13773249

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1N=C(c2ccccc2)S[C@@H]1C(=O)OCc1ccccc1

HCID13773251

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

3 次

PROCEDURE

实验过程

A stirred mixture of N-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine (3.1 g) and 1-hydroxybenzotriazole (1.7g) in dichloromethane (100ml) was treated with a solution of the product of step (a) (6.85g) in dichloromethane (25ml). A solution of dicyclohexylcarbodiimide (2.26g) in dichloromethane (20ml) was added over 20 minutes and the mixture was stirred at room temperature for 2 days under nitrogen.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5445dd6ca2954e948601577ca24be249
来源数据集: uspto-grants-1990_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04927822
来源说明: uspto-grants-1990_05

反应 SMILES

[CH2:1]([O:3][C:4]([C@@H:6]([NH:15][C@H:16]([C:18]([OH:20])=O)[CH3:17])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])[CH3:2].ON1C2C=CC=CC=2N=N1.[C:31]1([C:37]2[S:41][CH:40]([C:42]([O:44][CH2:45][C:46]3[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=3)=[O:43])[NH:39][N:38]=2)[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.C1(N=C=NC2CCCCC2)CCCCC1>ClCCl>[CH2:1]([O:3][C:4]([C@@H:6]([NH:15][C@H:16]([C:18]([N:39]1[N:38]=[C:37]([C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[S:41][C@@H:40]1[C:42]([O:44][CH2:45][C:46]1[CH:47]=[CH:48][CH:49]=[CH:50][CH:51]=1)=[O:43])=[O:20])[CH3:17])[CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:5])[CH3:2]