Pyrrolidine → HCID 13773263, compound

Participants

Reaction Steps

A solution of the product of step (c) (2.lg) and pyrrolidine (1.6ml) in dry acetonitrile (60ml) was treated with crushed 3A molecular sieves and the mixture stirred at room temperature for 24 hours under nitrogen. The volatile materials were removed by evaporation and the SSS isomer separated from the more polar SSR isomer by flash chromatography. The SSS sub-title product (0.47g) was isolated as a clear oil.

Provenance & Evidence