反应详情

温度

95 °C

A mixture of 5-t-butyl-2-methoxy-3-(chloroacetamido) phenyl-N-t-butyl-sulfonamide (8.0 g), aluminium chloride (16.4 g) and m-xylene (80 ml) was heated at 95° C. with stirring for 16 hours under nitrogen. The mixture was then poured into a beaker containing diethyl ether (300 ml) and water (300 ml) and stirred at ambient temperature for 15 minutes. The organic layer is separated and dried over sodium sulphate and concentrated under vacuum in order to remove all diethyl ether. The residual solution was cooled and hexane added to precipitate the title compound (4.7 g).

1. additionThe mixture was then poured into a beaker
2. stirringstirred at ambient temperature for 15 minutes
3. customThe organic layer is separated
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated under vacuum in order
6. customto remove all diethyl ether
7. temperatureThe residual solution was cooled
8. additionhexane added
9. customto precipitate the title compound (4.7 g)