反应详情

26.3 g of N-(2-fluoro-5-carboxyphenyl)-2,3-dimethylmaleic acid imide are introduced in portions, at 5°, into 230 ml of 96% sulphuric acid. There is then added dropwise to this mixture, while stirring vigorously at the same temperature, 5 ml of 100% nitric acid. The whole is further stirred overnight at room temperature and then poured onto ice. The product which precipitates is filtered with suction, washed with water, dried and recrystallised from acetonitrile. 28 g of N-(2-fluoro-5-carboxy-4-nitrophenyl)-2,3-dimethylmaleic acid imide which has a melting point of 264°-265° is thus obtained.

1. additionThere is then added dropwise to this mixture
2. additionpoured onto ice
3. customThe product which precipitates
4. filtrationis filtered with suction
5. washwashed with water
6. customdried
7. customrecrystallised from acetonitrile
8. customis thus obtained