Dichloromethane → HCID 70366955, compound

Participants

Reaction Conditions

Reaction Steps

N-methyl-1,2,6,7-tetrahydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine-6-methanamine (2.5 g), and diethyl oxalate (1.6 g), were combined and heated to 140° C. over a period of 45 min, then to 180° C. over 15 min. The reaction mixture was maintained at this temperature for 1 hr. The reaction mixture was cooled, dissolved in a small volume of dichloromethane, placed on a column of silica gel and eluted with 2.5% methanol-dichloromethane to yield 1.4 g, (46.7%) of product.

Provenance & Evidence