Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trichloroacetic Acid → 2-[3-(2-chloroethyl)-2-(2-chloroethylamino)-2-oxo-tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl-thio]-ethanesulphonic acid cyclohexylammonium salt
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trichloroacetic Acid | HCID 6421 | — |
| 반응물 | 4-Hydroxyifosfamide | HCID 308171 | — |
| 반응물 | 2-Sulfanylethane-1-sulfonic acid--cyclohexanamine (1/1) | HCID 23049873 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-[3-(2-chloroethyl)-2-(2-chloroethylamino)-2-oxo-tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl-thio]-ethanesulphonic acid cyclohexylammonium salt | HCID 131714976 | — |
반응 단계
277 mg (1 mmol) of 3-(2-chloroethyl)-2-(2-chloroethylamino)-hydroxy-tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide and 240 mg (1 mmol) of cyclohexylammonium-2-mercaptoethanesulphonate were dissolved in 4 ml of water, mixed with a trace of trichloroacetic acid and stored for 20 hours at 0° C. The reaction mixture which was concentrated under vacuum was dissolved twice in ethanol and re-concentrated. It was then taken up in ethanol and precipitated with ether.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04929607 |
| 출처 데이터셋 | uspto-grants-1990_05 |
| ORD ID | ord-23ae43a63d194921af6207ae62aea1bb |
| 출처 메모 | uspto-grants-1990_05 |