HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Meridia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sibutramine Hydrochloride | HCID 64764 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Meridia | HCID 64765 | — |
Reaction Steps
A sample (24.1 g) of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride was dissolved in a boiling mixture of water (72 ml) and tetrahydrofuran (7 ml) and the mixture allowed to cool. A solid was collected by filtration and dried at 40° C. to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate (m.p. 193°-195° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04929629 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-784cfccfc013465dae8167769f635e63 |
| Source note | uspto-grants-1990_05 |