Fumaric Acid → 125602-49-5

Participants

Reaction Steps

0.48 g (1.00 mmol) of 2-[2-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]ethylthio]benzoxazole obtained in Example 1 and 0.116 g (1.00 mmol) of fumaric acid were dissolved in 20 ml of ethanol, and the mixed clean solution was concentrated under reduced pressure. The residue was crystallized from isopropyl ether. The product was recrystallized from ethyl acetate to give 0.50 g (84%) of 2-[2-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]ethylthio]benzoxazole fumarate.

Provenance & Evidence