Potassium Carbonate → HCID 3079387, compound

Participants

Reaction Steps

To a mixture of 1.12 g (3.24 mmol) of 2-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]ethylamine obtained in Example 12 and 0.60 g (3.91 mmol) of 2-chlorobenzoxazole were added 0.57 g (4.12 mmol) of potassium carbonate and 5 ml of dioxane, and the mixture was stirred under heating at an oil-bath temperature of 80° to 85° C. for 3 hours. After the reaction, the insolubles were filtered off, and the filtrate was concentrated under reduced pressure. The residue was separated by silica gel column chromatography using chloroform as an eluent, and the desired fraction was concentrated under reduced pressure to give 0.72 g (48%) of 2-[2-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]ethylamino]benzoxazole as an oil.

Provenance & Evidence