Maleic Acid → HCID 131716392, compound

HRID 1651556Notes

Reaction equation

HRID 1651556 reaction equation
[C:1]1([CH:7]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][S:17][C:18]3[S:19][C:20]4[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=4[N:22]=3)[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:33]([OH:40])(=[O:39])/[CH:34]=[CH:35]\[C:36]([OH:38])=[O:37]>C(O)C>[C:33]([OH:40])(=[O:39])/[CH:34]=[CH:35]\[C:36]([OH:38])=[O:37].[C:33]([OH:40])(=[O:39])/[CH:34]=[CH:35]\[C:36]([OH:38])=[O:37].[C:27]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][S:17][C:18]3[S:19][C:20]4[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=4[N:22]=3)[CH2:12][CH2:13]2)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 131716393HCID 131716393, compound

Product 1

HCID 131716392HCID 131716392, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.70 g (1.52 mmol) of 2-[3-[4-(diphenylmethyl)-1-piperadinyl]propylthio]benzothiazole obtained in Example 21 was dissolved in 15 ml of ethanol, and 0.40 g (3.45 mmol) of maleic acid was added to the solution, and then the mixture was stirred at room temperature for about 2 hours. The precipitated crystals were collected, and recrystallized from ethanol to give 2-[3-[4-(diphenylmethyl)-1-piperadinyl]propylthio]benzothiazole dimaleate.

Workup

  1. customThe precipitated crystals were collected
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-ab968fa143a84a2ca36169e6c7eb18a2
Source dataset
uspto-grants-1990_05
Patent number
US04929618

Reaction notes

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