反应详情

温度

80 °C

2.00 g (6.61 mmol) of 4-[(4-chlorophenyl)-2-pyridylmethoxy]piperidine and 1.43 g (7.90 mmol) of ethyl 3-bromopropionate were dissolved in 10 ml of dioxane, and 1.09 g (7.89 mmol) of potassium carbonate was added to the mixed solution, and then the mixture was stirred under heating at an oil bath temperature of around 80° C. for 8 hours. After the reaction, the insolubles were filtered off, and the filtrate was concentrated under reduced pressure. The residue was separated by silica gel column chromatography using a solvent mixture of chloroform and methanol in the volume ratio 19:1 as are eluent. The desired fraction was concentrated under reduced pressure to give 1.78 g (67%) of ethyl 3-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]-propionate.

1. customAfter the reaction
2. filtrationthe insolubles were filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue was separated by silica gel column chromatography
5. additiona solvent mixture of chloroform and methanol in the volume ratio 19:1
6. concentrationThe desired fraction was concentrated under reduced pressure