HCID 14770840, compound → HCID 54318584, compound

HRID 1651569Notes

Reaction equation

HRID 1651569 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[C:5]([F:15])=[CH:4][C:3]=1[C:16](=[O:23])[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19]>C(OC(=O)C)(=O)C.C(OCC)(OCC)OCC>[CH2:18]([O:20][CH:21]=[C:17]([C:16](=[O:23])[C:3]1[CH:4]=[C:5]([F:15])[C:6]([CH:8]2[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH2:13]2)=[CH:7][C:2]=1[F:1])[C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:17]

Participants

4

Reactant 1

HCID 14770840HCID 14770840, compound

Product 1

HCID 54318584HCID 54318584, compound

Reagents, catalysts & solvents 2

HCID 7918Acetic AnhydrideSolventHCID 31214Ethyl orthoformateSolvent

Procedure

A solution of 3.25 g (10 mmoles) of ethyl 2,5-difluoro4-(1-methyl-4-piperidinyl)-β-oxobenzenepropionate in 20 ml of acetic anhydride and 2.5 ml of triethyl orthoformate was refluxed 11/4 hours and evaporated under vacuum to give the title compound.

Workup

  1. customevaporated under vacuum

Sources & evidence

ORD record
ord-3e58054936b9443aba2da4645839674f
Source dataset
uspto-grants-1990_05
Patent number
US04929613

Reaction notes

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