Acetic Anhydride → HCID 14770847, compound

HRID 1651579Notes

Reaction equation

HRID 1651579 reaction equation
[NH2:1][CH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]([F:16])=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[C:9]([F:17])[CH:8]=2)[CH2:3]1.[C:18](OC(=O)C)(=[O:20])[CH3:19]>C(O)(=O)C>[C:18]([NH:1][CH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]([F:16])=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[C:9]([F:17])[CH:8]=2)[CH2:3]1)(=[O:20])[CH3:19]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 14770846HCID 14770846, compound

Product 1

HCID 14770847HCID 14770847, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 24.1 g (0.1 mol) of 4-[3-(amino)cyclopentyl]-2,5-difluorobenzoic acid in a mixture of 50 ml of acetic anhydride and 100 ml of acetic acid was heated at reflux for 6 hours. The solvent was removed in vacuo and the residue triturated with water. The solid was removed by filtration, washed with water, and dried in vacuo to give 25.3 g of the title compound.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 6 hours
  3. customThe solvent was removed in vacuo
  4. customthe residue triturated with water
  5. customThe solid was removed by filtration
  6. washwashed with water
  7. customdried in vacuo

Sources & evidence

ORD record
ord-0b1c0b3b90da4082b592ae26233f0c73
Source dataset
uspto-grants-1990_05
Patent number
US04929613

Reaction notes

Loading…