反应详情

A solution of 24.1 g (0.1 mol) of 4-[3-(amino)cyclopentyl]-2,5-difluorobenzoic acid in a mixture of 50 ml of acetic anhydride and 100 ml of acetic acid was heated at reflux for 6 hours. The solvent was removed in vacuo and the residue triturated with water. The solid was removed by filtration, washed with water, and dried in vacuo to give 25.3 g of the title compound.

1. temperaturewas heated
2. temperatureat reflux for 6 hours
3. customThe solvent was removed in vacuo
4. customthe residue triturated with water
5. customThe solid was removed by filtration
6. washwashed with water
7. customdried in vacuo